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Review
. 2010 May-Jun;23(3):244-7.
doi: 10.1111/j.1525-139X.2010.00721.x. Epub 2010 May 10.

Potential effects of MYH9-associated nephropathy on dialysis and kidney transplant outcomes

Barry I Freedman  1 , Mariana Murea
Affiliations
Review

Potential effects of MYH9-associated nephropathy on dialysis and kidney transplant outcomes

Barry I Freedman et al. Semin Dial. 2010 May-Jun.

Abstract

Several related disorders comprise the spectrum of nonmuscle myosin heavy chain 9-associated (MYH9) nephropathy. The contribution of variants in this single MYH9 gene to ethnic differences in the incidence rates of end-stage renal disease is now clearly established. The importance of recognizing the role of MYH9 in these inherited kidney disorders goes beyond simple disease association; there may well be effects on clinical outcomes in patients on dialysis and after kidney transplantation. MYH9 polymorphisms may affect treatment outcomes in severe kidney disease and such gene effects are rarely encountered in practice.

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References

    1. Kopp JB, Smith MW, Nelson GW, Johnson RC, Freedman BI, Bowden DW, et al. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet. 2008;40:1175–84. - PMC - PubMed
    1. Kao WH, Klag MJ, Meoni LA, Reich D, Berthier-Schaad Y, Li M, et al. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet. 2008;40:1185–92. - PMC - PubMed
    1. Freedman BI, Hicks PJ, Bostrom MA, Cunningham ME, Liu Y, Divers J, et al. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. Kidney Int. 2009;75:736–45. - PMC - PubMed
    1. Pattaro C, Aulchenko YS, Isaacs A, Vitart V, Hayward C, Franklin CS, et al. Genome-wide linkage analysis of serum creatinine in three isolated European populations. Kidney Int. 2009;76:297–306. - PubMed
    1. Franceschini N, Voruganti VS, Haack K, Almasy L, Laston S, Goring HH, et al. The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study. Hum Genet. 2009 ePub. - PMC - PubMed

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