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. 2010 May 24:11:78.
doi: 10.1186/1471-2350-11-78.

No association between polymorphisms of WNT2 and schizophrenia in a Korean population

Hak-Jae Kim  1 , Jin Kyung Park, Su Kang Kim, Sung Wook Kang, Jong Woo Kim, Hyun-Kyung Park, Ah-Rang Cho, Ji Young Song, Joo-Ho Chung
Affiliations

No association between polymorphisms of WNT2 and schizophrenia in a Korean population

Hak-Jae Kim et al. BMC Med Genet. .

Abstract

Background: Wingless-type MMTV integration site family member 2 (WNT2) has a potentially important role in neuronal development; however, there has yet to be an investigation into the association between single nucleotide polymorphisms (SNPs) of WNT2 and schizophrenia. This study aimed to determine whether certain SNPs of WNT2 were associated with schizophrenia in a Korean population.

Methods: e genotyped 7 selected SNPs in the WNT2 gene region (approximately 46 Kb) using direct sequencing in 288 patients with schizophrenia and 305 healthy controls.

Results: Of the SNPs examined, one SNP showed a weak association with schizophrenia (p = 0.017 in the recessive model). However, this association did not remain statistically significant after Bonferroni correction.

Conclusion: The present study does not support a major role for WNT2 in schizophrenia. This could be due to the size of the population. Therefore, additional studies would be needed to definitively rule out the gene's minor effects.

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Figures

Figure 1
Figure 1
Gene map and single nucleotide polymorphisms (SNPs) in the WNT2 gene on chromosome 7q31.2. Exons are marked with boxes. The coding regions are black boxes. The first nucleotide is denoted as +1. The arrow indicates the location of each SNP.
Figure 2
Figure 2
Linkage disequilibrium (LD) blocks of the WNT2 gene. LD coefficient (|D'|) and LD blocks among WNT2 SNPs. Block 1 consists of rs4730775 and rs2024233. Block 2 comprises rs3779548 and rs17132543.
See this image and copyright information in PMC

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