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. 1986;8(1):115-20.
doi: 10.1016/0197-0186(86)90108-7.

Acute effects of ammonia on the enzymes of citric acid cycle in rat brain

L Ratnakumari  1 , G Y Subbalakshmi, C R Murthy
Affiliations

Acute effects of ammonia on the enzymes of citric acid cycle in rat brain

L Ratnakumari et al. Neurochem Int. 1986.

Abstract

Activities of the enzymes of citric acid cycle were determined along with aspartate and alanine aminotransferases and NADP(+)-isocitrate dehydrogenase in the brains of rats treated with an acute dose of ammonium acetate and compared with those of normal animals. Elevation in the activities of pyruvate, ?-ketoglutarate and succinate dehydrogenases and citrate synthase was observed in hyperammonemic animals. The activities of malate, NADP(+)-isocitrate dehydrogenases and aminotransferases decreased under these conditions. The results suggest that ammonia toxicity might not be due to the depletion of ?-ketoglutarate from citric acid cycle.

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