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. 2010 Jul;73(2):146-51.
doi: 10.1016/j.bandc.2010.04.007. Epub 2010 May 20.

Functional imaging of working memory and peripheral endothelial function in middle-aged adults

Mitzi M Gonzales  1 , Takashi Tarumi, Hirofumi Tanaka, Jun Sugawara, Tali Swann-Sternberg, Katayoon Goudarzi, Andreana P Haley
Affiliations

Functional imaging of working memory and peripheral endothelial function in middle-aged adults

Mitzi M Gonzales et al. Brain Cogn. 2010 Jul.

Abstract

The current study examined the relationship between a prognostic indicator of vascular health, flow-mediated dilation (FMD), and working memory-related brain activation in healthy middle-aged adults. Forty-two participants underwent functional magnetic resonance imaging while completing a 2-Back working memory task. Brachial artery endothelial-dependent flow-mediated dilation (FMD) was assessed using B-mode ultrasound. The relationship between FMD and task-related brain activation in a priori regions of interest was modeled using hierarchical linear regression. Brachial FMD, was significantly related to reduced working memory-related activation in the right superior parietal lobule (beta=0.338, p=0.027), independent of age, sex, systolic blood pressure, and full scale IQ (F(5,36)=2.66, p=0.038). These data provide preliminary support for the association between a preclinical marker of endothelial dysfunction and cerebral hemodynamic alterations in healthy middle-aged adults. Considering the modifiable nature of endothelial function, additional investigations on the prognostic significance of FMD on future cognitive impairment are warranted.

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Figure 1
Figure 1
Figure 2
Figure 2
Scatterplot of Flow-Mediated Dilation and Mean Task-Related Activation Intensity in the Right Superior Parietal Lobule
See this image and copyright information in PMC

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