Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
- PMID: 20493806
- PMCID: PMC2883254
- DOI: 10.1016/j.devcel.2010.04.008
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development
Abstract
The two major components of the kidney, the collecting system and the nephron, have different developmental histories. The collecting system arises by the reiterated branching of a simple epithelial tube, while the nephron forms from a cloud of mesenchymal cells that coalesce into epithelial vesicles. Each develops into a morphologically complex and highly differentiated structure, and together they provide essential filtration and resorption functions. In this review, we will consider their embryological origin and the genes controlling their morphogenesis, patterning, and differentiation, with a focus on recent advances in several areas.
Copyright 2010 Elsevier Inc. All rights reserved.
Figures




References
-
- Airik R, Kispert A. Down the tube of obstructive nephropathies: the importance of tissue interactions during ureter development. Kidney Int. 2007;72:1459–1467. - PubMed
-
- Barak H, Rosenfelder L, Schultheiss TM, Reshef R. Cell fate specification along the anterior-posterior axis of the intermediate mesoderm. Dev Dyn. 2005;232:901–914. - PubMed
-
- Basson MA, Akbulut S, Watson-Johnson J, Simon R, Carroll TJ, Shakya R, Gross I, Martin GR, Lufkin T, McMahon AP, et al. Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell. 2005;8:229–239. - PubMed
-
- Bort R, Signore M, Tremblay K, Martinez Barbera JP, Zaret KS. Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev Biol. 2006;290:44–56. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases