Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Sep 10;584(17):3779-84.
doi: 10.1016/j.febslet.2010.05.024. Epub 2010 May 21.

Pot1 and telomere maintenance

Peter Baumann  1 , Carolyn Price
Affiliations
Review

Pot1 and telomere maintenance

Peter Baumann et al. FEBS Lett. .

Abstract

Proteins that specifically bind the single-stranded overhang at the ends of telomeres have been identified in a wide range of eukaryotes and play pivotal roles in chromosome end protection and telomere length regulation. Here we summarize recent findings regarding the functions of POT1 proteins in vertebrates and discuss the functional evolution of POT1 proteins following gene duplication in protozoa, plants, nematodes and mice.

PubMed Disclaimer

Figures

Figure 1
Figure 1
POT1 regulation of telomerase and RPA access to the 3′ overhang. (A) POT1 prevents telomerase access by sequestering the DNA terminus. Telomere is shown in a closed state. (B) During S-phase an alternative mode of binding makes the 3′ terminus accessible to telomerase. TPP1 stimulates telomerase processivity. (C) POT1 removal leads to RPA binding and activation of an ATR-mediated DNA damage response.
See this image and copyright information in PMC

References

    1. de Lange T, Lundblad V, Blackburn EH. Telomeres. Cold Spring Harbor Laboratory Press; New York: 2006.
    1. Autexier C, Lue NF. The structure and function of telomerase reverse transcriptase. Annu Rev Biochem. 2006;75:493–517. - PubMed
    1. Froelich-Ammon SJ, Dickinson BA, Bevilacqua JM, Schultz SC, Cech TR. Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha. Genes Dev. 1998;12:1504–1514. - PMC - PubMed
    1. Chai W, Du Q, Shay JW, Wright WE. Human telomeres have different overhang sizes at leading versus lagging strands. Mol Cell. 2006;21:427–435. - PubMed
    1. Wei C, Price M. Protecting the terminus: t-loops and telomere end-binding proteins. Cell Mol Life Sci. 2003;60:2283–2294. - PMC - PubMed

Publication types