Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jun;31(5):386-92.
doi: 10.1097/DBP.0b013e3181dea44f.

Increased oxidative stress in healthy children following an exercise program: a pilot study

Melita M Nasca  1 , Renliang Zhang, Dennis M Super, Stanley L Hazen, Howard R Hall
Affiliations

Increased oxidative stress in healthy children following an exercise program: a pilot study

Melita M Nasca et al. J Dev Behav Pediatr. 2010 Jun.

Abstract

Exercise can induce oxidative stress or an imbalance between reactive oxygen species and cellular antioxidant defenses.

Objective: We investigated the effect of a real-life exercise program on systemic oxidative stress measured by urinary concentrations of 8-isoprostaglandin F2alpha (8-iso-PGF2 alpha), a noninvasive index of lipid peroxidation, in a well-characterized pediatric group.

Methods: Healthy but primarily sedentary, 8- to 10-year-old children (n = 6, mean age 8.8 +/- 0.9 years) of equally distributed healthy weight, overweight, and obese categories, participated in a 5-week exercise program (track and field summer camp, 2 hours/day, 1-2 days/week).

Results: By using high-performance liquid chromatography with online electrospray ionization tandem mass spectrometry (LC/ESI/MS/MS), we found a significant (p = .028) increase in group mean urinary 8-iso-PGF2 alpha concentration from 8.163 +/- 6.919 ng/mg creatinine pre-exercise program to 32.320 +/- 16.970 ng/mg creatinine post-exercise program. The increase was also measured at each individual level. We found preliminary evidence that pre- and post-exercise program urinary 8-iso-PGF2 alpha concentrations selectively correlated with children's cardiometabolic characteristics and mood.

Conclusion: Our results warrant further exploration of the relationships between pre/post-exercise oxidative stress marker 8-iso-PGF2 alpha and cardiometabolic characteristics, exercise habits, eating habits, and mood to determine whether increased post-exercise oxidative stress in healthy children is part of their normal adaptation to exercise or mediator of oxidative injury.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Individual increase in concentrations of urinary 8-isoprostaglandin F2α one of the F2-IsoPs, a marker of systemic oxidative stress, indexed to creatinine in 6 healthy children from pre-exercise program to post-exercise program time point. Group mean urinary F2-IsoPs increase is represented in bold (p = .028, Wilcoxon signed ranks test).
See this image and copyright information in PMC

References

    1. US Department of Health and Human Services. Physical Activity and Health: a Report of the Surgeon General. Atlanta, GA: CDC; 1996.
    1. Warburton DE, Nicol CW, Bredin SS. Health benefits of physical activity: the evidence. CMAJ. 2006;174:801–809. - PMC - PubMed
    1. Urso ML, Clarkson PM. Oxidative stress, exercise, and antioxidant supplementation. Toxicology. 2003;189:41–54. - PubMed
    1. Balog T, Sobocanec S, Sverko V, et al. The influence of season on oxidant-antioxidant status in trained and sedentary subjects. Life Sci. 2006;78:1441–1447. - PubMed
    1. Ozbay B, Dulger H. Lipid peroxidation and antioxidant enzymes in Turkish population: relation to age, gender, exercise, and smoking. Tohoku J Exp Med. 2002;197:119–124. - PubMed

Publication types