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Review
. 2010 Jun;17(6):666-72.
doi: 10.1038/nsmb.1842. Epub 2010 May 23.

Post-translational modifications in signal integration

Yonathan Lissanu Deribe  1 , Tony Pawson, Ivan Dikic
Affiliations
Review

Post-translational modifications in signal integration

Yonathan Lissanu Deribe et al. Nat Struct Mol Biol. 2010 Jun.

Abstract

Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.

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