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Review
. 2010 Jun;16(6):653-61.
doi: 10.1038/nm.2165. Epub 2010 May 23.

Missing pieces in the Parkinson's disease puzzle

Jose A Obeso  1 , Maria C Rodriguez-Oroz, Christopher G Goetz, Concepcion Marin, Jeffrey H Kordower, Manuel Rodriguez, Etienne C Hirsch, Matthew Farrer, Anthony H V Schapira, Glenda Halliday
Affiliations
Review

Missing pieces in the Parkinson's disease puzzle

Jose A Obeso et al. Nat Med. 2010 Jun.

Abstract

Parkinson's disease is a neurodegenerative process characterized by numerous motor and nonmotor clinical manifestations for which effective, mechanism-based treatments remain elusive. Here we discuss a series of critical issues that we think researchers need to address to stand a better chance of solving the different challenges posed by this pathology.

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