Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Sep;257(9):1421-31.
doi: 10.1007/s00415-010-5591-7. Epub 2010 May 22.

Neurological adverse events associated with anti-tumor necrosis factor α treatment

Antonio G Tristano  1
Affiliations
Review

Neurological adverse events associated with anti-tumor necrosis factor α treatment

Antonio G Tristano. J Neurol. 2010 Sep.

Abstract

Anti-tumor necrosis factor alpha (TNF-alpha) drugs have been successfully used for the treatment of rheumatic autoimmune diseases including rheumatoid arthritis (RA), psoriatic arthritis, psoriasis, ankylosing spondylitis (AS), juvenile chronic arthritis, and Crohn's disease. However, they have been associated with different neurological disorders, including alterations of peripheral nerves, multiple sclerosis (MS), optic neuritis (ON) and acute transverse myelitis (ATM). This article reviews the most current aspect regarding neurological adverse events associated with anti-TNF-alpha drugs with emphasis on the possible explanations for this relation and the pathogenic mechanism of TNF-alpha in neurological disorders.

PubMed Disclaimer

Comment in

References

    1. Eur J Gastroenterol Hepatol. 2006 May;18(5):565-6 - PubMed
    1. J Inflamm. 1995-1996;47(1-2):8-17 - PubMed
    1. Neurology. 2001 Mar 13;56(5):666-9 - PubMed
    1. J Neuroinflammation. 2008 Oct 17;5:45 - PubMed
    1. J Neuroimmunol. 1997 Feb;72(2):163-8 - PubMed

MeSH terms

Substances