Insulin secretion and impaired glucose tolerance

Comment

A B Jenkins et al. Diabetologia. 2010 Oct.

. 2010 Oct;53(10):2266-8; author reply 2269-70; discussion 2271-2.

doi: 10.1007/s00125-010-1801-1. Epub 2010 May 22.

No abstract available

Comment on

Determinants of glucose tolerance in impaired glucose tolerance at baseline in the Actos Now for Prevention of Diabetes (ACT NOW) study.
DeFronzo RA, Banerji MA, Bray GA, Buchanan TA, Clement S, Henry RR, Kitabchi AE, Mudaliar S, Musi N, Ratner R, Reaven P, Schwenke DC, Stentz FD, Tripathy D; ACT NOW Study Group. DeFronzo RA, et al. Diabetologia. 2010 Mar;53(3):435-45. doi: 10.1007/s00125-009-1614-2. Epub 2009 Dec 10. Diabetologia. 2010. PMID: 20012012 Clinical Trial.
Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance.
Mari A, Tura A, Natali A, Laville M, Laakso M, Gabriel R, Beck-Nielsen H, Ferrannini E; RISC Investigators. Mari A, et al. Diabetologia. 2010 Apr;53(4):749-56. doi: 10.1007/s00125-009-1647-6. Epub 2010 Jan 9. Diabetologia. 2010. PMID: 20225397