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. 1991 Jul 1;68(1):195-7.
doi: 10.1002/1097-0142(19910701)68:1<195::aid-cncr2820680135>3.0.co;2-l.

Natural history of vaginal intraepithelial neoplasia

M Aho  1 , E Vesterinen, B Meyer, E Purola, J Paavonen
Affiliations

Natural history of vaginal intraepithelial neoplasia

M Aho et al. Cancer. .

Abstract

The natural history of vaginal intraepithelial neoplasia (VAIN) was studied in 23 patients followed for at least 3 years with no treatment. The mean age of the patients was 41 years of age. A large proportion of the VAIN lesions (50%) were multifocal, and approximately one half of the lesions were associated with concomitant cervical or vulvar intraepithelial neoplasia. Progression to invasive vaginal carcinoma occurred in two (9%) cases, persistence of VAIN occurred in three (13%) cases, and regression of VAIN occurred in 18 (78%) cases. The risk for progression to invasive carcinoma emphasizes the significance of colposcopic examination of the vagina with directed biopsy specimens obtained from all lesions.

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