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. 2009 Sep;8(3):248-259.
doi: 10.2174/187152309789152020.

Neonatal Necrotizing Enterocolitis -Inflammation and Intestinal Immaturity

Erika C Claud  1
Affiliations

Neonatal Necrotizing Enterocolitis -Inflammation and Intestinal Immaturity

Erika C Claud. Antiinflamm Antiallergy Agents Med Chem. 2009 Sep.

Abstract

Neonatal necrotizing enterocolitis is a devastating inflammatory bowel disease of premature infants. The pathogenesis remains incompletely understood and there is no specific treatment. Efforts are ongoing to understand aspects of intestinal immaturity which contribute to susceptibility to this disease. This review focuses on bacterial colonization patterns, intestinal barrier function, and inflammatory responses of immature enterocytes leading to a unique vulnerability of the preterm gut. In addition the possible therapeutic potential of factors in human milk and probiotic bacteria is discussed.

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Figures

Fig. 1
Fig. 1
Aspects of immature intestinal host defense in the premature infant that may contribute to susceptibility to necrotizing enterocolitis. Reproduced with permission [146].
Fig. 2
Fig. 2
Nuclear factor kappa B signaling cascade. Asterisks denote steps with differential response to inflammatory stimuli in immature and mature intestinal epithelial cells.
See this image and copyright information in PMC

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References

    1. Martin JA, Kung HC, Mathews TJ, Hoyert DL, Strobino DM, Guyer B, Sutton SR. Annual summary of vital statistics: 2006. Pediatrics. 2008;121(4):788–801. - PubMed
    1. Van Marter LJ, Dammann O, Allred EN, Leviton A, Pagano M, Moore M, Martin C. Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants. J Pediatr. 2002;140(2):171–176. - PubMed
    1. Blahnik MJ, Ramanathan R, Riley CR, Minoo P. Lipopolysaccharide-induced tumor necrosis factor-alpha and IL-10 production by lung macrophages from preterm and term neonates. Pediatr Res. 2001;50(6):726–731. - PubMed
    1. Chheda S, Palkowetz KH, Garofalo R, Rassin DK, Goldman AS. Decreased interleukin-10 production by neonatal monocytes and T cells: relationship to decreased production and expression of tumor necrosis factor-alpha and its receptors. Pediatr Res. 1996;40(3):475–483. - PubMed
    1. Jones CA, Cayabyab RG, Kwong KY, Stotts C, Wong B, Hamdan H, Minoo P, de Lemos RA. Undetectable interleukin (IL)-10 and persistent IL-8 expression early in hyaline membrane disease: a possible developmental basis for the predisposition to chronic lung inflammation in preterm newborns. Pediatr Res. 1996;39(6):966–975. - PMC - PubMed