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. 2010 Jul 15;26(14):1804-5.
doi: 10.1093/bioinformatics/btq264. Epub 2010 May 25.

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base

George Khelashvili  1 , Kevin Dorff, Jufang Shan, Marta Camacho-Artacho, Lucy Skrabanek, Bas Vroling, Michel Bouvier, Lakshmi A Devi, Susan R George, Jonathan A Javitch, Martin J Lohse, Graeme Milligan, Richard R Neubig, Krzysztof Palczewski, Marc Parmentier, Jean-Philippe Pin, Gerrit Vriend, Fabien Campagne, Marta Filizola
Affiliations

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base

George Khelashvili et al. Bioinformatics. .

Abstract

Summary: Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically. Based on an ontology derived from a community dialog involving colleagues using experimental and computational methodologies, we developed the GPCR-Oligomerization Knowledge Base (GPCR-OKB). GPCR-OKB is a system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature. While focused on GPCR oligomers, GPCR-OKB is seamlessly connected to GPCRDB, facilitating the correlation of information about GPCR protomers and oligomers.

Availability and implementation: The GPCR-OKB web application is freely available at http://www.gpcr-okb.org

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References

    1. Ferre S, et al. Building a new conceptual framework for receptor heteromers. Nat. Chem. Biol. 2009;5:131–134. - PMC - PubMed
    1. Hopkins AL, Groom CR. The druggable genome. Nat. Rev. Drug Discov. 2002;1:727–730. - PubMed
    1. Horn F, et al. GPCRDB information system for G protein-coupled receptors. Nucleic Acids Res. 2003;31:294–297. - PMC - PubMed
    1. Milligan G, Bouvier M. Methods to monitor the quaternary structure of G protein-coupled receptors. FEBS J. 2005;272:2914–2925. - PubMed
    1. Nemoto W, et al. GRIP: a server for predicting interfaces for GPCR oligomerization. J. Recept. Signal. Transduct. Res. 2009;29:312–317. - PubMed

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