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. 1991;40(4):363-5.
doi: 10.1007/BF00265844.

CSF baclofen levels after intrathecal administration in severe spasticity

B Sallerin-Caute  1 , Y Lazorthes, B Monsarrat, J Cros, R Bastide
Affiliations

CSF baclofen levels after intrathecal administration in severe spasticity

B Sallerin-Caute et al. Eur J Clin Pharmacol. 1991.

Abstract

The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l.h-1. In order to optimize treatment, it is suggested that CSF baclofen levels be matched to changes in Hoffman's monosynaptic reflex (H reflex).

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