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. 1991 Jan 25;193(1):15-9.
doi: 10.1016/0014-2999(91)90194-u.

[Pro34]neuropeptide Y selectively identifies postjunctional-mediated actions of neuropeptide Y in vivo in rats and dogs

E K Potter  1 , J Fuhlendorff, T W Schwartz
Affiliations

[Pro34]neuropeptide Y selectively identifies postjunctional-mediated actions of neuropeptide Y in vivo in rats and dogs

E K Potter et al. Eur J Pharmacol. .

Abstract

Anaesthetised rats and dogs were used to study the pre- and postjunctional actions of neuropeptide Y (NPY) and [Pro34]NPY simultaneously. Increases in arterial blood pressure indicated postjunctional actions and both NPY and [Pro34]NPY elicited these. Change in pulse interval evoked by stimulation of the cut peripheral end of the right vagus nerve, indicated prejunctional action of the peptides: NPY caused prolonged attenuation of vagal action in rats and dogs but [Pro34]NPY did not attenuate vagal action in rats or dogs.

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