Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jun;26(3):265-71.
doi: 10.1007/s12264-010-1217-4.

Modulation of the activity of dopaminergic neurons by SK channels: a potential target for the treatment of Parkinson's disease?

Xiao-Kun Liu  1 , Gang Wang, Sheng-Di Chen
Affiliations
Review

Modulation of the activity of dopaminergic neurons by SK channels: a potential target for the treatment of Parkinson's disease?

Xiao-Kun Liu et al. Neurosci Bull. 2010 Jun.

Abstract
in English, Chinese

SK channels are small conductance calcium-activated potassium channels that are widely expressed in different neurons with distinct subtypes. They play an important role in modulating synaptic plasticity, dopaminergic neurotransmission, and learning and memory. The present review was mainly focused on the recent findings on the contradictory roles of SK channels in modulating dopaminergic neurons in substantia nigra and in the pathogenesis of Parkinson's disease (PD). Besides, whether modulation of SK channels could be a potential target for PD treatment was also discussed.

小电导钙激活钾通道也即SK 通道, 其广泛表达于不同亚型的神经元中, 在调节突触可塑性、学习与记忆和多巴胺能神经传递过程中发挥重要作用。 本文重点讨论了SK通道调节黑质多巴胺能神经元的作用及其在帕金森病发病机制中的争议性角色, 并对调控SK 通道是否可成为一种新的治疗帕金森病的方法进行了探讨。

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Faber E.S., Sah P. Functions of SK channels in central neurons. Clin Exp Pharmacol Physiol. 2007;34:1077–1083. doi: 10.1111/j.1440-1681.2007.04725.x. - DOI - PubMed
    1. Blank T., Nijholt I., Kye M.J., Spiess J. Small conductance Ca2+-activated K+ channels as targets of CNS drug development. Curr Drug Targets CNS Neurol Disord. 2004;3:161–167. doi: 10.2174/1568007043337472. - DOI - PubMed
    1. Wang G., Zeng J., Ren R., Chen S. Potassium channels in the basal ganglia: promising new targets for the treatment of Parkinson’s disease. Front Biosci. 2008;13:3825–3838. doi: 10.2741/2971. - DOI - PubMed
    1. Zeng J., Wang G., Chen S.D. ATP-sensitive potassium channels: novel potential roles in Parkinson’s disease. Neurosci Bull. 2007;23:370–376. doi: 10.1007/s12264-007-0055-5. - DOI - PMC - PubMed
    1. Pedarzani P., Stocker M. Molecular and cellular basis of smalland intermediate-conductance,calcium-activated potassium channel function in the brain. Cell Mol Life Sci. 2008;65:3196–3217. doi: 10.1007/s00018-008-8216-x. - DOI - PMC - PubMed

Publication types

MeSH terms

Substances