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Comparative Study
. 1991 Mar-Apr;19(2):115-22.
doi: 10.1007/BF01645581.

Linkage and independence of AIDS and Kaposi disease: the interaction of human immunodeficiency virus and some coagents

H J Eggers  1 , J J Weyer
Affiliations
Comparative Study

Linkage and independence of AIDS and Kaposi disease: the interaction of human immunodeficiency virus and some coagents

H J Eggers et al. Infection. 1991 Mar-Apr.

Abstract
in English, German

Through epidemiological considerations we conclude that full-blown AIDS may occur only if the index patient is infected by the human immunodeficiency virus (HIV) and, in addition, by some other infectious coagent. Since the dynamical behavior of the spread of AIDS cases with manifestation of Kaposi's sarcoma differs fundamentally from that of the non-Kaposi cases, we conjecture that two independent coagents (together with HIV) are responsible for the outbreak of full-blown AIDS with or without manifestation of Kaposi's sarcoma, respectively. Our formal epidemiological considerations appear to be supported by recent microbiological findings.

Aufgrund epidemiologischer Überlegungen wird geschlossen, daß Voll-AIDS möglicherweise nur dann auftritt, wenn der entsprechende Patient mit dem humanen Immundefizienzvirus (HIV) und außerdem mit einem weiteren infektiösen Koagens infiziert ist. Da sich die Ausbreitungsdynamik der AIDS-Fälle mit Manifestation von Kaposi-Sarkom wesentlich von der der Fälle ohne Kaposi-Sarkom unterscheidet, wird vermutet, daß für die Ausprägung von AIDS mit bzw. ohne Beteiligung von Kaposi-Sarkom jeweils eigenständige Koagenzien verantwortlich sind. Unsere formalen epidemiologischen Argumente scheinen durch neuere mikrobiologische Ergebnisse gestützt zu werden.

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