doi: 10.1007/BF03091772.
The effect of insulin on the heart: Part 2: Effects on function during and post myocardial ischaemia
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- PMID: 20505799
- PMCID: PMC2871746
- DOI: 10.1007/BF03091772
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The effect of insulin on the heart: Part 2: Effects on function during and post myocardial ischaemia
Neth Heart J.
2010 May.
Abstract
Insulin infusion has been advocated in the treatment of myocardial ischaemia and myocardial infarction. There is evidence from experimental animal studies for a protective effect of high-dose insulin administration in myocardial ischaemia and myocardial infarction. In some relatively small study populations a reduction in mortality was reported in those patients who received glucose-insulin-potassium (GIK) during myocardial infarction, which was confirmed in two meta-analyses. However, it has not been possible to reproduce these positive results in large randomised clinical trials. (Neth Heart J 2010;18:255-9.).
Keywords: Cardiomyopathy; Founder Effect; Mutation; Myosin-binding Protein C.
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