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. 2010 Jun;16(6):943-7.
doi: 10.3201/eid1606.100089.

New measles virus genotype associated with outbreak, China

Yan Zhang  1 , Zhengrong Ding, Huiling Wang, Liqun Li, Yankun Pang, Kevin E Brown, Songtao Xu, Zhen Zhu, Paul A Rota, David Featherstone, Wenbo Xu
Affiliations

New measles virus genotype associated with outbreak, China

Yan Zhang et al. Emerg Infect Dis. 2010 Jun.

Abstract

To determine the origin of the virus associated with a measles outbreak in Menglian County, Yunnan Province, People's Republic of China, in 2009, we conducted genetic analyses. Phylogenetic analyses based on nucleoprotein (N) and hemagglutinin (H) gene sequences showed that these Menglian viruses were not closely related to sequences of any World Health Organization (WHO) reference strains representing the 23 currently recognized genotypes. The minimum nucleotide divergence between the Menglian viruses and the most closely related reference strain, genotype D7, was 3.3% for the N gene and 3.0% for the H gene. A search of the databases of GenBank, WHO, and the Health Protection Agency Measles Nucleotide Surveillance showed that the Menglian viruses, together with the 2 older non-Menglian viruses, could be members of a new proposed measles genotype, d11. The new genotype designation will allow for better description of measles transmission patterns, especially in the Southeast Asian and Western Pacific regions.

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Figures

Figure 1
Figure 1
Phylogenetic analysis of the sequences of the nucleoprotein genes (450 nt) of the strains of measles virus from Menglian County, Yunnan Province, People’s Republic of China. The unrooted tree shows sequences from Menglian viruses (circles) compared with World Health Organization (WHO) reference strains for each genotype. Triangles indicate D7 WHO reference strains; diamonds, the 2 older non-Menglian strains. Genotype designation is in boldface. MV, measles virus; MVi, measles virus sequence from isolates; MVs, measles virus sequence from clinical specimens. Scale bar indicates base substitutions per site.
Figure 2
Figure 2
Phylogenetic analysis of the sequences of the hemagglutinin genes of the strains of measles virus from Menglian County, Yunnan Province, People’s Republic of China. The unrooted tree shows sequences from the Menglian viruses (circles) compared with World Health Organization reference strains for each genotype. Genotype designation is in boldface. MVi, measles virus sequence from isolates; MV, measles virus; MVs, measles virus sequence from clinical specimens; wt, wild type. Scale bar indicates base substitutions per site.
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