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. 2010 Jun;16(6):1000-2.
doi: 10.3201/eid1606.100066.

Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract

Nicole Fischer  1 , Claudia Schulz, Kristin Stieler, Oliver Hohn, Christoph Lange, Christian Drosten, Martin Aepfelbacher
Affiliations

Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract

Nicole Fischer et al. Emerg Infect Dis. 2010 Jun.

Abstract

Xenotropic murine leukemia virus-related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. To identify nucleic acid sequences, we examined respiratory secretions by using PCR. XMRV-specific sequences were detected in 2%-3% of samples from 168 immunocompetent carriers and approximately 10% of samples from 161 immunocompromised patients.

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Figures

Figure
Figure
Xenotropic murine leukemia virus–related gammaretrovirus (XMRV) gag sequences derived from respiratory tract secretions. Phylogenetic tree comparing the 390-nt gag fragment of all respiratory samples of this study with recently published XMRV sequences from patients with familial prostate cancer (1). The edited sequences were aligned with ClustalX version 1.82 (13,14) by using default settings. The tree was generated on the basis of positions without gaps only. Sequences are labeled as X, xenotropic; P, polytropic; mP, modified polytropic; S, sputum, IS, immunosuppression; TS, tracheal secretion; and C, control. Scale bar indicates nucleotide substitutions per position.
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References

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