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Review
. 2010 Jun;33(6):1389-94.
doi: 10.2337/dc09-2082.

Hypoglycemia, diabetes, and cardiovascular events

Affiliations
Review

Hypoglycemia, diabetes, and cardiovascular events

Cyrus V Desouza et al. Diabetes Care. 2010 Jun.
No abstract available

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Figures

Figure 1
Figure 1
Mechanisms by which hypoglycemia may affect cardiovascular events. Hypoglycemic events may trigger inflammation by inducing the release of C-reactive protein (CRP), IL-6, and vascular endothelial growth factor (VEGF). Hypoglycemia also induces increased platelet and neutrophil activation. The sympathoadrenal response during hypoglycemia increases adrenaline secretion and may induce arrhythmias and increase cardiac workload. Underlying endothelial dysfunction leading to decreased vasodilation may also contribute to cardiovascular risk.

References

    1. Gore MO, McGuire DK: The 10-year post-trial follow-up of the United Kingdom Prospective Diabetes Study (UKPDS): cardiovascular observations in context. Diab Vasc Dis Res 2009;6:53–55 - PubMed
    1. Keen H: The Diabetes Control and Complications Trial (DCCT). Health Trends 1994;26:41–43 - PubMed
    1. Egeli ES, Berkmen R: Action of hypoglycemia on coronary insufficiency and mechanism of ECG alterations. Am Heart J 1960;59:527–540 - PubMed
    1. Fisman EZ, Motro M, Tenenbaum A, Leor J, Boyko V, Mandelzweig L, Sherer Y, Adler Y, Behar S: Is hypoglycaemia a marker for increased long-term mortality risk in patients with coronary artery disease? An 8-year follow-up. Eur J Cardiovasc Prev Rehabil 2004;11:135–143 - PubMed
    1. Judson WE, Hollander W: The effects of insulin-induced hypoglycemia in patients with angina pectoris: before and after intravenous hexamethonium. Am Heart J 1956;52:198–209 - PubMed

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