Meibomian gland duct distortion in patients with perennial allergic conjunctivitis
- PMID: 20508507
- DOI: 10.1097/ICO.0b013e3181ca3668
Meibomian gland duct distortion in patients with perennial allergic conjunctivitis
Abstract
Purpose: To observe morphologic changes of meibomian glands in patients with and without perennial allergic conjunctivitis (AC) and to assess the relation between morphologic changes of the meibomian glands of both eyelids and tear film parameters.
Methods: In this study, 55 eyes of 55 patients with perennial AC and 47 eyes of 47 healthy volunteers as controls were included. The following tests were performed: a slit-lamp examination, measurement of tear film breakup time, grading of meibomian gland morphologic changes (meibography score) assessed with a noncontact meibography, meibomian gland duct distortion in meibography, tear production by the Schirmer I test, and grading of meibum expression.
Results: The frequency of meibomian gland duct distortion was significantly greater in patients with AC (45%) than that in controls (8.5%; P < 0.0001). The meibum (P = 0.049) and superficial punctate keratopathy scores (P = 0.0076) were significantly higher in patients with AC than those in controls. There was no significant difference in meibography score, breakup time, or Schirmer value between the 2 groups. The meibomian expression score was significantly higher in patients with AC with meibomian gland duct distortion than in patients with AC without meibomian gland duct distortion (P = 0.0012).
Conclusion: Perennial AC is associated with increased meibomian gland duct distortion.
Similar articles
-
Association of contact lens-related allergic conjunctivitis with changes in the morphology of meibomian glands.Jpn J Ophthalmol. 2012 Jan;56(1):14-9. doi: 10.1007/s10384-011-0103-6. Epub 2011 Nov 23. Jpn J Ophthalmol. 2012. PMID: 22109632
-
Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population.Ophthalmology. 2008 May;115(5):911-5. doi: 10.1016/j.ophtha.2007.06.031. Ophthalmology. 2008. PMID: 18452765
-
Contact lens wear is associated with decrease of meibomian glands.Ophthalmology. 2009 Mar;116(3):379-84. doi: 10.1016/j.ophtha.2008.10.012. Epub 2009 Jan 22. Ophthalmology. 2009. PMID: 19167077
-
Validity of noninvasive meibography systems: noncontact meibography equipped with a slit-lamp and a mobile pen-shaped meibograph.Cornea. 2013 Nov;32 Suppl 1:S65-70. doi: 10.1097/ICO.0b013e3182a2c7c6. Cornea. 2013. PMID: 24104937 Review.
-
A review of meibography.Optom Vis Sci. 2012 May;89(5):E760-9. doi: 10.1097/OPX.0b013e3182512ac1. Optom Vis Sci. 2012. PMID: 22488268 Review.
Cited by
-
Beyond dry eye: how co-morbidities influence disease phenotype in dry eye disease.Clin Exp Optom. 2022 Mar;105(2):177-185. doi: 10.1080/08164622.2021.1962210. Epub 2021 Aug 8. Clin Exp Optom. 2022. PMID: 34369296 Free PMC article. Review.
-
Meibomian gland atrophy in children with allergic conjunctivitis.Int J Ophthalmol. 2025 May 18;18(5):832-839. doi: 10.18240/ijo.2025.05.07. eCollection 2025. Int J Ophthalmol. 2025. PMID: 40385119 Free PMC article.
-
Differentiation between chalazion and sebaceous carcinoma by noninvasive meibography.Clin Ophthalmol. 2014 Sep 18;8:1869-75. doi: 10.2147/OPTH.S69804. eCollection 2014. Clin Ophthalmol. 2014. PMID: 25258508 Free PMC article.
-
Association of meibomian gland morphology with orifice plugging and lid margin thickening in meibomian gland dysfunction patients.Int Ophthalmol. 2023 Sep;43(9):3207-3218. doi: 10.1007/s10792-023-02721-2. Epub 2023 May 4. Int Ophthalmol. 2023. PMID: 37140834
-
Eyelid Contact Dermatitis: 25-Year Single-Center Retrospective Study.J Clin Med. 2025 Jan 27;14(3):823. doi: 10.3390/jcm14030823. J Clin Med. 2025. PMID: 39941494 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical