Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Apr;58(4):357-61.
doi: 10.4097/kjae.2010.58.4.357. Epub 2010 Apr 28.

Comparison of the effects of acetaminophen to ketorolac when added to lidocaine for intravenous regional anesthesia

Myoung Jin Ko  1 , Jeong Han Lee, Soon Ho Cheong, Chee Mahn Shin, Young Jae Kim, Young Kyun Choe, Kun Moo Lee, Se Hun Lim, Young Hwan Kim, Kwang Rae Cho, Sang Eun Lee
Affiliations

Comparison of the effects of acetaminophen to ketorolac when added to lidocaine for intravenous regional anesthesia

Myoung Jin Ko et al. Korean J Anesthesiol. 2010 Apr.

Abstract

Background: This study was done to evaluate the effect on pain relief when acetaminophen was added to lidocaine for intravenous regional anesthesia (IVRA).

Methods: SIXTY PATIENTS UNDERGOING HAND OR FOREARM SURGERY RECEIVED IVRA WERE ASSIGNED TO THREE GROUPS: Group C received 0.5% lidocaine diluted with 0.9% normal saline to a total volume of 40 ml (n = 20), Group P received 0.5% lidocaine diluted with intravenous acetaminophen 300 mg to a total volume of 40 ml (n = 20) and Group K received 0.5% lidocaine diluted with 0.9% normal saline plus ketorolac 10 mg made up to a total volume of 40 ml (n = 20). Sensory block onset time, tourniquet pain onset time, which was defined as the time from tourniquet application to fentanyl administration for relieving tourniquet pain and amount of analgesic consumption during surgery were recorded. Following deflation of tourniquet sensory recovery time, postoperative pain and quantity of analgesic uses in post-anesthesia care unit were assessed.

Results: Sensory block onset time was shorter in Group P compared to Group C (P < 0.05). Tourniquet pain onset time was delayed in Group P when compared with group C (P < 0.05). Postoperative pain and analgesic consumption were reduced in Group P and Group K compared to Group C (P < 0.001).

Conclusions: The addition of acetaminophen to lidocaine for IVRA shortens the onset time of sensory block and delays tourniquet pain onset time, but not with ketorolac. Both acetaminophen and ketorolac reduce postoperative pain and analgesic consumption.

Keywords: Acetaminophen; Intravenous regional anesthesia; Ketorolac; Paracetamol.

PubMed Disclaimer

References

    1. Brill S, Middleton W, Brill G, Fisher A. Bier's block; 100 years old and still going strong! Acta Anaesthesiol Scand. 2004;48:117–122. - PubMed
    1. Choyce A, Peng P. A systematic review of adjuncts for intravenous regional anaesthesia for surgical procedure. Can J Anesth. 2002;49:32–45. - PubMed
    1. So KY, Kim HJ, Go WS. Intravenous regional anesthesia using mepivacaine and tramadol. Korean J Anesthesiol. 2002;42:172–176.
    1. Gentili M, Bernard JM, Bonnet F. Adding clonidine to lidocaine for intravenous regional anesthesia prevents tourniquet pain. Anesth Analg. 1999;88:1327–1330. - PubMed
    1. Kang KS, Jung SH, Ahn KR, Kim CS, Kim JE, Yoo SH, et al. The effects of neostigmine added to ropivacaine for intravenous regional anesthesia. Korean J Anesthesiol. 2004;47:649–654.

LinkOut - more resources