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. 2010 Aug;27(8):463-8.
doi: 10.1007/s10815-010-9437-0. Epub 2010 May 27.

Recent cadmium exposure among male partners may affect oocyte fertilization during in vitro fertilization (IVF)

Keewan Kim  1 , Victor Y Fujimoto, Patrick J Parsons, Amy J Steuerwald, Richard W Browne, Michael S Bloom
Affiliations

Recent cadmium exposure among male partners may affect oocyte fertilization during in vitro fertilization (IVF)

Keewan Kim et al. J Assist Reprod Genet. 2010 Aug.

Abstract

Purpose: We recently reported evidence suggesting associations between urine cadmium concentrations, reflecting long-term exposure, measured in 25 female patients (relative risk = 1.41, P = 0.412) and 15 of their male partners (relative risk = 0.19, P = 0.097) and oocyte fertilization in vitro. Blood cadmium concentrations reflect more recent exposure.

Methods: We here incorporate those measures into our prior data set and employ multivariable log-binomial regression models to generate hypotheses concerning the relative effects of long-term and recent cadmium exposure on oocyte fertilization in vitro.

Results: No association is indicated for blood cadmium from women and oocyte fertilization, adjusted for urine cadmium and creatinine, blood lead and mercury, age, race/ethnicity and cigarette smoking (relative risk = 0.88, P = 0.828). However, we suggest an inverse adjusted association between blood cadmium from men and oocyte fertilization (relative risk = 0.66, P = 0.143).

Conclusions: These results suggest that consideration of long-term and recent exposures are both important for assessing the effect of partner cadmium levels on oocyte fertilization in vitro.

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References

    1. Bloom MS, Parsons PJ, Steuerwald AJ, Schisterman EF, Browne RW, Kim K. Toxic trace metals and human oocytes during in vitro fertilization (IVF) Reprod Toxicol. 2010;29:298–305. doi: 10.1016/j.reprotox.2010.01.003. - DOI - PMC - PubMed
    1. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for cadmium. Atlanta, GA 1999 - PubMed
    1. Lauwerys R, Bernard A, Roels H, Buchet J. Cadmium: exposure markers as predictors of nephrotoxic effects. Clin Chem. 1994;40:1391–4. - PubMed
    1. Palmer CD, Lewis ME, Jr, Geraghty CM, Barbosa F, Jr, Parsons PJ. Determination of lead, cadmium and mercury in blood for assessment of environmental exposure: a comparison between inductively coupled plasma-mass spectrometry and atomic absorption spectrometry. Spectrochim Acta Part B Atom Spectrosc. 2006;61:980–90. doi: 10.1016/j.sab.2006.09.001. - DOI
    1. Schisterman EF, Vexler A, Whitcomb BW, Liu A. The limitations due to exposure detection limits for regression models. Am J Epidemiol. 2006;163:374–83. doi: 10.1093/aje/kwj039. - DOI - PMC - PubMed

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