Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010;9(2):106-14.
doi: 10.1080/15332641003772587.

Association of race and ethnicity with withdrawal symptoms, attrition, opioid use, and side-effects during buprenorphine therapy

E Sherwood Brown  1 , Carlos Tirado, Abu Minhajuddin, Maureen Hillhouse, Bryon Adinoff, Walter Ling, Geetha Doraimani, Christie Thomas
Affiliations

Association of race and ethnicity with withdrawal symptoms, attrition, opioid use, and side-effects during buprenorphine therapy

E Sherwood Brown et al. J Ethn Subst Abuse. 2010.

Abstract

Some studies report differences in opioid withdrawal between racial/ethnic groups. However, it is not known if these differences are reflected in differential treatment response. Data from National Institute on Drug Abuse (NIDA) Clinical Trials Network-003 were used to examine racial/ethnic differences before and during stabilization with buprenorphine. At induction, non-Hispanic Caucasians had higher objective and subjective withdrawal scores and greater opioid craving than minority participants. No significant between-group differences were observed on these scales following buprenorphine. Non-Hispanic Caucasians and Hispanics reported more adverse events than African Americans. Although ethnic and racial differences were observed prior to buprenorphine treatment, scores following buprenorphine treatment were similar between groups.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Study Phases
See this image and copyright information in PMC

References

    1. Administration, S. A. a. M. H. S. Analysis of Substance Abuse and Treatment Need Issues, Table of Contents (TOC) 2008 2008b from http://www.drugabusestatistics.samhsa.gov/treatan/toc.htm.
    1. Bickel WK, Stitzer ML, Bigelow GE, Liebson IA, Jasinski DR, Johnson RE. A clinical trial of buprenorphine: comparison with methadone in the detoxification of heroin addicts. Clin Pharmacol Ther. 1988;43(1):72–78. - PubMed
    1. Booth BM, Blow FC, Cook CAL, Bunn JY, Fortney JC. Age and ethnicity among hospitalized alcoholics: A nationwide study. Alcoholism: Clinical and Experimental Research. 1992;16(6):1029–1034. - PubMed
    1. Compton WM, Conway KP, Stinson FS, Colliver JD, Grant BF. Prevalence, correlates, and comorbidity of DSM-IV antisocial personality syndromes and alcohol and specific drug use disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions. J Clin Psychiatry. 2005;66(6):677–685. - PubMed
    1. Huang B, Dawson DA, Stinson FS, Hasin DS, Ruan WJ, Saha TD, et al. Prevalence, correlates, and comorbidity of nonmedical prescription drug use and drug use disorders in the United States: Results of the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2006;67(7):1062–1073. - PubMed

MeSH terms