TGF-Beta to the rescue
- PMID: 20510867
- DOI: 10.1016/j.immuni.2010.04.014
TGF-Beta to the rescue
Abstract
Is transforming growth factor-beta (TGF-beta) required for induction of the transcription factor Foxp3 in developing thymocytes? Ouyang et al. (2010) demonstrate that TGF-beta in the thymus prevents deletion of Foxp3(+) regulatory T cells.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development.Immunity. 2010 May 28;32(5):642-53. doi: 10.1016/j.immuni.2010.04.012. Epub 2010 May 13. Immunity. 2010. PMID: 20471291 Free PMC article.
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