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Comment
. 2010 May 28;32(5):590-2.
doi: 10.1016/j.immuni.2010.05.004.

Double duty for CCL21 in dendritic cell trafficking

Philip M Murphy  1
Affiliations
Comment

Double duty for CCL21 in dendritic cell trafficking

Philip M Murphy. Immunity. .

Abstract

Mechanisms controlling leukocyte adhesion, propulsion and directional migration have not been fully integrated. In this issue of Immunity, Schumann et al. (2010) propose that DCs swarm to T cell zones using immobilized CCL21 for adhesive random migration and soluble CCL21 for steering.

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Figures

Figure 1
Figure 1
CCL21 regulation of mature dendritic cell trafficking to T cell zones. In this model, proposed by Schumann et al. (2010), DCs undergo adhesive random migration (thin arrows) on fields of immobilized CCL21 (large red symbols) and ICAM-1 (not shown) that becomes directionally biased in response to concentration gradients of truncated soluble CCL21 (small red symbols), generated from the immobilized chemokine by the DC itself. Soluble CCL21 forms gradients and biases the direction of migration (thick arrow).
See this image and copyright information in PMC

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