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Comment
. 2010 May 28;141(5):750-2.
doi: 10.1016/j.cell.2010.05.013.

For synapses, it's depression not death

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For synapses, it's depression not death

Helen S Bateup et al. Cell. .
Free article

Abstract

Long-term depression (LTD) of synaptic strength is an activity-dependent process in neurons that may be important for learning and memory. Li et al. (2010) now reveal a new apoptosis-independent role for mitochondrial-activated caspases in LTD suggesting that neurons have co-opted the canonical cell death pathway to perform a specialized function at synapses.

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