For synapses, it's depression not death
- PMID: 20510921
- DOI: 10.1016/j.cell.2010.05.013
For synapses, it's depression not death
Abstract
Long-term depression (LTD) of synaptic strength is an activity-dependent process in neurons that may be important for learning and memory. Li et al. (2010) now reveal a new apoptosis-independent role for mitochondrial-activated caspases in LTD suggesting that neurons have co-opted the canonical cell death pathway to perform a specialized function at synapses.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.Cell. 2010 May 28;141(5):859-71. doi: 10.1016/j.cell.2010.03.053. Cell. 2010. PMID: 20510932 Free PMC article.
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