Comment
doi: 10.1016/j.cell.2010.05.012.
Viral houseguests undertake interior redesign
Affiliations
- PMID: 20510923
- PMCID: PMC9880789
- DOI: 10.1016/j.cell.2010.05.012
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Comment
Viral houseguests undertake interior redesign
Cell.
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Abstract
As part of their life cycle some single-stranded RNA viruses remodel host cytoplasmic membranes into specialized organelles. In this issue, Hsu et al. (2010) demonstrate how the viruses selectively co-opt host machinery to make this unique organelle, which has a lipid composition favorable to viral replication.
Copyright 2010 Elsevier Inc. All rights reserved.
Figures
Secretory Pathway Manipulation by Viruses In an uninfected cell (left) the guanosine exchange factor GBF1 and the small GTPase Arf1 recruit the coat protein COPI to the membrane for formation of transport vesicles between the Golgi and the ER-Golgi intermediate compartment (ERGIC). In a cell infected by a positive-sense single-stranded RNA virus (right) the virally encoded protein 3A utilizes GBF1 and ARF1 to recruit the phospholipid-modifying enzyme, phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ). This enzyme catalyzes the production of phosphatidylinositol-4-phosphate (PI4P), which in turn binds the viral RNA polymerase leading to formation of the replication organelle.
Comment on
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Viral reorganization of the secretory pathway generates distinct organelles for RNA replication.Cell. 2010 May 28;141(5):799-811. doi: 10.1016/j.cell.2010.03.050. Cell. 2010. PMID: 20510927 Free PMC article.