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Review
. 2010 Jun;85(6):560-6; quiz 566.
doi: 10.4065/mcp.2010.0137.

Managing aromatase inhibitors in breast cancer survivors: not just for oncologists

Affiliations
Review

Managing aromatase inhibitors in breast cancer survivors: not just for oncologists

Julia A Files et al. Mayo Clin Proc. 2010 Jun.

Abstract

The role of the general internist in the care of breast cancer survivors is increasing as the number of women living with breast cancer continues to rise. Most breast cancers occurring in women older than 50 years are estrogen receptor- and/or progesterone receptor-positive, and adjuvant endocrine therapy plays an important role in the treatment plan. Aromatase inhibitors are becoming the preferred endocrine therapy, and general internists caring for breast cancer survivors need to be familiar with their use and adverse effect profile. This article reviews the use of aromatase inhibitors, the frequency of common adverse effects, and strategies for their management.

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Figures

FIGURE.
FIGURE.
Management of genitourinary atrophy in patients receiving aromatase inhibitor (AI) therapy. STD = sexually transmitted disease.

References

    1. Detailed Guide: Breast Cancer: What are the Key Statitics for Breast Cancer? American Cancer Society Web site. http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_What_are_the_key_st... http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_What_are_the_key_st... Accessed April 27, 2010.
    1. Li CI, Daling JR, Malone KE. Incidence of invasive breast cancer by hormone receptor status from 1992 to 1998. J Clin Oncol. 2003;21(1):28-34 - PubMed
    1. Altundag K, Ibrahim NK. Aromatase inhibitors in breast cancer: an overview. Oncologist 2006;11(6):553-562 - PubMed
    1. Early Breast Cancer Trialists' Collaborative Group (EBCTCG) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;365(9472):1687-1717 - PubMed
    1. Baum M, Budzar AU, Cuzick J, et al. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet 2002;359(9324):2131-2139 - PubMed

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