Comment
doi: 10.1016/j.molcel.2010.05.008.
A metabolic (re-)balancing act
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- PMID: 20513422
- DOI: 10.1016/j.molcel.2010.05.008
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Comment
A metabolic (re-)balancing act
Mol Cell.
.
Free article
Abstract
Cells lacking a functional tuberous sclerosis complex (TSC) heterodimer are sensitized to glucose starvation-induced death. In this issue of Molecular Cell, Choo et al. (2010) report that reducing energy consumption allows these cells to survive on glutamine as an alternative energy source.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply.Mol Cell. 2010 May 28;38(4):487-99. doi: 10.1016/j.molcel.2010.05.007. Mol Cell. 2010. PMID: 20513425 Free PMC article.
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