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Comment
. 2010 May 28;38(4):484-6.
doi: 10.1016/j.molcel.2010.05.005.

When push comes to shove: SWI/SNF uses a nucleosome to get rid of a nucleosome

Ning Liu  1 , Jeffrey J Hayes
Affiliations
Comment

When push comes to shove: SWI/SNF uses a nucleosome to get rid of a nucleosome

Ning Liu et al. Mol Cell. .

Abstract

A report in this issue of Molecular Cell (Dechassa et al., 2010) provides evidence that a translocating SWI/SNF-nucleosome complex efficiently displaces neighboring nucleosomes in vitro and may account for SWI/SNF-dependent nucleosome eviction in vivo.

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Figures

Figure
Figure
Proposed mechanism of SWI/SNF nucleosome eviction. Top of figure shows unperturbed chromatin with two nucleosomes. SWI/SNF is recruited by the transcription factor (Gal4-VP16, yellow hexagon) and binds the proximal nucleosome. SWI/SNF remodels the nucleosome in its active site and translocates in one direction along the DNA. Upon encountering the downstream nucleosome, an H2A dimer is first displaced, followed by eviction of the entire neighboring nucleosome from the DNA template.
See this image and copyright information in PMC

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