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Review
. 2010 Jun;88(6):404-8.

[Renal involvement in Behcet's disease]

[Article in French]
Mondher Ounissi  1 , Khaoula Ben Abdelghani, Taher Gargueh, Sami Turki, Rym Goucha, Ezzedine Abderrahim, Fathi Ben Hamida, Hedi Ben Maiz, Adel Khedher
Affiliations
  • PMID: 20517850
Free article
Review

[Renal involvement in Behcet's disease]

[Article in French]
Mondher Ounissi et al. Tunis Med. 2010 Jun.
Free article

Abstract

Background: Renal involvement in the Behcet's disease is rare. The clinical features vary from urinary sediment's abnormalities to ESRD.

Aim: We propose to study the clinical, biological and histological data, the therapeutic management and the prognosis of patients.

Methods: We report a retrospective study including 8 patients representing 1.23 % of cases.

Results: The average age of the patient was of 37 +/- 12. 35 years with a clear male prevalence. Urinary signs were discovered fortuitously by the strips in the majority of the cases after an average of 18 months. It's about proteinuria and hematuria. Renal insufficiency and hypertension were rare. Pathological study highlighted 3 cases of amyloidosis, 2 cases of IgA nephropathy, 1 case of minimal change disease, 1 case of endo and extracapillary glomerulonephritis and 1 case of interstitial nephropathy. Patients having GN were treated by corticoids and immunosuppressive agents and those having an interstitial nephropathy were treated symptomatically with good evolution in the majority of the cases. Only one patient is dead, he had amyloidosis. Prognosis depended on the precocity of the diagnosis, the histological type and the treatment.

Conclusion: The renal involvement during Behçet's disease is rare. Amyloidosis and Ig A nephropathy are the most frequent. Treatment is still controversial.

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