Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Mar 16;50 Suppl 5(Suppl 5):S23-6.

[New perspectives on Alzheimer's disease from neuroimaging]

[Article in Spanish]
James T Becker  1
Affiliations

[New perspectives on Alzheimer's disease from neuroimaging]

[Article in Spanish]
James T Becker. Rev Neurol. .

Abstract
in English, Spanish

Introduction and development: Over the next 50 years, the proportion of the population over the age of 65 will increase dramatically, and the number of individuals with neurodegenerative dementias such as Alzheimer's disease will rise, as well. Current pharmacological and non-pharmacological treatment strategies have focused on the symptomatic phases of Alzheimer's disease, but with the ability to identify the disease earlier in its clinical course comes an increased under-standing of the factors that alter the risk of expressing the clinical syndrome.

Conclusions: Neuroimaging studies are now revealing that many of the conditions that normally afflict individuals as they become older also have effects on the structural integrity of the brain. Successful management of these conditions, especially if combined with other therapeutic interventions, could extend the dementia-free time and decrease the burden to the patient, family, and to society.

Introducción y desarrollo: En los próximos 50 años vamos a presenciar un incremento significativo de la población mayor de 65 años y por lo tanto va a aumentar, considerablemente, el número de individuos con riesgo de desarrollar demencias neurodegenerativas, especialmente la enfermedad de Alzheimer (EA). Las estrategias actuales de tratamiento farmacológico y no farmacológico se han centrado en las fases sintomáticas de esta enfermedad y, gradualmente, vamos teniendo una mayor comprensión de los posibles factores de riesgo del síndrome clínico.

Conclusiones: Los estudios de neuroimagen han sido muy útiles para mostrar los cambios estructurales del envejecimiento normal y patológico, así como también los factores de riesgo para la EA. Los tratamientos apropiados de los factores de riesgo y su posible combinación con tratamientos específicos para la EA podrían prolongar el período presintomático de la EA y, por tanto, mejorar la calidad de vida y disminuir la carga para el paciente, la familia y la sociedad.

PubMed Disclaimer

Conflict of interest statement

Conflictos de interés: El autor declara haber recibido apoyo financiero de Grifols.

References

    1. Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer’s disease in the United States and the public health impact of delaying disease onset. Am J Public Health. 1998;88:1337–42. - PMC - PubMed
    1. Lopez OL, Becker JT, Wisniewski S, Saxton J, Kaufer DI, DeKosky ST. Cholinesterase inhibitor treatment alters the natural history of Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2002;72:310–4. - PMC - PubMed
    1. Lopez OL, Becker JT, Saxton J, Sweet R, Klunk W, DeKosky ST. Alteration of a clinically meaningful outcome in the natural history of Alzheimer’s disease by cholinesterase inhibition. J Am Geriatr Soc. 2005;53:83–7. - PubMed
    1. Lopez OL, Becker JT, Wahed AS, Saxton J, Sweet RA, Wolk DA, et al. Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease. J Neurol Neurosurg Psychiatry. 2009;80:600–7. - PMC - PubMed
    1. Tárraga L, Boada M, Modinos G, Espinosa A, Diego S, Morera A, et al. A randomised pilot study to assess the e@cacy of an interactive, multimedia tool of cognitive stimulation in Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2006;77:1116–21. - PMC - PubMed

Publication types

LinkOut - more resources