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Review
. 2010 Jun 7;16(21):2633-7.
doi: 10.3748/wjg.v16.i21.2633.

Heme oxygenase-1 system and gastrointestinal tumors

Xiao Zhu  1 , Wen-Guo Fan, Dong-Pei Li, Marie C M Lin, Hsiangfu Kung
Affiliations
Review

Heme oxygenase-1 system and gastrointestinal tumors

Xiao Zhu et al. World J Gastroenterol. .

Abstract

Heme oxygenase-1 (HO-1) system catabolizes heme into three products: carbon monoxide, biliverdin/bilirubin and free iron. It is involved in many physiological and pathophysiological processes. A great deal of data has demonstrated the roles of HO-1 in the formation, growth and metastasis of tumors. The interest in this system by investigators involved in gastrointestinal tumors is fairly recent, and few papers on HO-1 have touched upon this subject. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal tumors studied to date. The implications for possible therapeutic manipulation of HO-1 in gastrointestinal tumors are also discussed.

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Figures

Figure 1
Figure 1
Schematic demonstration of mechanism underlying the biological actions of HO-1 pathway in tumors. HO-1: Heme oxygenase-1; CO: Carbon monoxide; sGC/cGMP: Soluble guanylate cyclase/cyclic guanosine monophosphate; MAPK: Mitogen-activated protein kinase.
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