Genetics: Gonadotropin deficiency in genetic form of congenital hypogonadotropic hypogonadism is of hypothalamic origin

Comment

Linda Koch. Nat Rev Endocrinol. 2010 Jun.

. 2010 Jun;6(6):298.

doi: 10.1038/nrendo.2010.55.

No abstract available

Comment on

TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans.
Young J, Bouligand J, Francou B, Raffin-Sanson ML, Gaillez S, Jeanpierre M, Grynberg M, Kamenicky P, Chanson P, Brailly-Tabard S, Guiochon-Mantel A. Young J, et al. J Clin Endocrinol Metab. 2010 May;95(5):2287-95. doi: 10.1210/jc.2009-2600. Epub 2010 Mar 1. J Clin Endocrinol Metab. 2010. PMID: 20194706

Molecular and Genetic Aspects of Congenital Isolated Hypogonadotropic Hypogonadism.
Lima Amato LG, Latronico AC, Gontijo Silveira LF. Lima Amato LG, et al. Endocrinol Metab Clin North Am. 2017 Jun;46(2):283-303. doi: 10.1016/j.ecl.2017.01.010. Epub 2017 Feb 23. Endocrinol Metab Clin North Am. 2017. PMID: 28476224 Review.
Congenital cerebellar hypoplasia and hypogonadotropic hypogonadism.
Abs R, Van Vleymen E, Parizel PM, Van Acker K, Martin M, Martin JJ. Abs R, et al. J Neurol Sci. 1990 Sep;98(2-3):259-65. doi: 10.1016/0022-510x(90)90267-q. J Neurol Sci. 1990. PMID: 2243234
Causes of hypogonadotropic hypogonadism predict response to gonadotropin substitution in adults.
Rohayem J, Sinthofen N, Nieschlag E, Kliesch S, Zitzmann M. Rohayem J, et al. Andrology. 2016 Jan;4(1):87-94. doi: 10.1111/andr.12128. Andrology. 2016. PMID: 26779870
Congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
Golden MP, Lippe BM, Kaplan SA. Golden MP, et al. Am J Dis Child. 1977 Oct;131(10):1117-8. doi: 10.1001/archpedi.1977.02120230063010. Am J Dis Child. 1977. PMID: 910763
Genetics of congenital hypogonadotropic hypogonadism: peculiarities and phenotype of an oligogenic disease.
Cangiano B, Swee DS, Quinton R, Bonomi M. Cangiano B, et al. Hum Genet. 2021 Jan;140(1):77-111. doi: 10.1007/s00439-020-02147-1. Epub 2020 Mar 21. Hum Genet. 2021. PMID: 32200437 Review.