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. 2010;81 Suppl 1(Suppl 1):19-29.

The concept of multiple hormonal dysregulation

Marcello Maggio  1 , Chiara Cattabiani, Fulvio Lauretani, Luigi Ferrucci, Michele Luci, Giorgio Valenti, Gianpaolo Ceda
Affiliations

The concept of multiple hormonal dysregulation

Marcello Maggio et al. Acta Biomed. 2010.

Abstract

Aging process is accompanied by hormonal changes characterized by an imbalance between catabolic hormones that remain stable and anabolic hormones (testosterone, insulin like growth factor-1 (IGF-1) and dehydroepiandrosterone sulphate (DHEAS), that decrease with age. Despite the multiple hormonal dysregulation occurring with age, the prevalent line of research in the last decades has tried to explain many age-related phenomena as consequence of one single hormonal derangement with disappointing results. In this review we will list the relationship between hormonal anabolic deficiency and frailty and mortality in older population, providing evidence to the notion that multiple hormonal dysregulation rather than change in single anabolic hormone is a powerful marker of poor health status and mortality.

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Figures

Figure 1
Figure 1
Overview of the hypothesized molecular, physiological, and clinical pathway to frailty focusing on the potential interaction between gene variation, oxidative stress and neuroendocrine dysregulation in the development of frailty (Adapted from Ref 9)
See this image and copyright information in PMC

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