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. 1991 Apr;13(3):221-5.

Total and free valproic acid: plasma level/dose ratio in monotherapy

J A Abadín  1 , J A Durán, A Sánchez, J S Serrano
Affiliations
  • PMID: 2051846

Total and free valproic acid: plasma level/dose ratio in monotherapy

J A Abadín et al. Methods Find Exp Clin Pharmacol. 1991 Apr.

Abstract

Free plasma level/dose ratio of valproic acid (L/D-F) can be more effective than total plasma level/dose ratio (L/D-T) in adjusting dosage regimens. The influence of age, dose, and plasma concentration have been studied on L/D-T and L/D-F ratios. L/D-T and L/D-F ratios from 67 outpatients under long-term monotherapy were obtained. Analytical data was carried out by fluorescent polarized immunoassay. L/D-T and L/D-F ratios do not vary according to age. L/D-T and L/D-F ratios decreased while the dosage increased; both ratios increased with an increase in total plasma level of valproic acid. Significant differences were found between L/D-T and L/D-F ratios. Dose and interindividual variations are the factors which most influence L/D ratios of valproic acid.

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