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. 2010 Jun 23;132(24):8276-7.
doi: 10.1021/ja103544p.

Gold(I)-catalyzed enantioselective polycyclization reactions

Steven G Sethofer  1 , Timo Mayer, F Dean Toste
Affiliations

Gold(I)-catalyzed enantioselective polycyclization reactions

Steven G Sethofer et al. J Am Chem Soc. .

Abstract

A series of enantioselective polycyclization reactions, catalyzed by a cationic bisphosphine gold complexes, are described. The polycyclization reactions, which employ an alkyne as an initiating group, begin with a gold-promoted 6-exo-dig cyclization and can be terminated with a variety of nucleophiles including carboxylic acids, phenols, sulfonamides, and electron-rich aryl groups. This method allows for the preparation of up to four bonds in a single operation with excellent diastereo- and enantioselectivity.

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