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Editorial
. 2010;12(3):107.
doi: 10.1186/bcr2571. Epub 2010 Jun 1.

What do we learn from HER2-positive breast cancer genomic profiles?

Charles Theillet
Editorial

What do we learn from HER2-positive breast cancer genomic profiles?

Charles Theillet. Breast Cancer Res. 2010.

Abstract

Patients with a tumor presenting amplification of the HER2 gene are currently proposed trastuzumab (herceptin) and this has greatly changed their outcome. However, a number of HER2-positive cancers show intrinsic or acquired resistance to trastuzumab and there are clear indications that they form a heterogeneous group of tumors. A paper in this issue of Breast Cancer Research addresses this heterogeneity at the genomic level.

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References

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