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Comment
. 2010;11(6):122.
doi: 10.1186/gb-2010-11-6-122. Epub 2010 Jun 1.

Dramatic changes in transcription factor binding over evolutionary time

Matthew T Weirauch  1 , Timothy R Hughes
Affiliations
Comment

Dramatic changes in transcription factor binding over evolutionary time

Matthew T Weirauch et al. Genome Biol. 2010.

Abstract

A recent study reveals a surprisingly high degree of change in the occupancy patterns of two transcription factors in the livers of five vertebrates.

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Figures

Figure 1
Figure 1
Summary of cross-species TF occupancy comparisons. Phylogenetic trees illustrating occupancy patterns of CEPBA in the livers of five vertebrates. Red numbers indicate the frequency of each depicted scenario. Green ovals indicate the presence of a TF binding event for the given species at a particular locus. Blue dashed ovals indicate presence in at least two of the three placental mammals; orange dashed ovals indicate presence in at least one of the three. H, human; M, mouse; D, dog; O, opossum; C, chicken. (a-c) Binding events presumably conserved since the common ancestor of placental mammals (a), all mammals (b), or mammals and birds (c), but lost in one or more lineages. (d) Binding events that are apparently invariant in all mammals and birds examined.
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