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Case Reports
. 2010;49(11):991-4.
doi: 10.2169/internalmedicine.49.3153. Epub 2010 Jun 1.

A patient with advanced hepatocellular carcinoma treated with sorafenib tosylate showed massive tumor lysis with avoidance of tumor lysis syndrome

Satoru Joshita  1 , Kaname Yoshizawa, Kenji Sano, Satoshi Kobayashi, Tomohiro Sekiguchi, Susumu Morita, Atsushi Kamijo, Michiharu Komatsu, Takeji Umemura, Tetsuya Ichijo, Akihiro Matsumoto, Eiji Tanaka
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Free article
Case Reports

A patient with advanced hepatocellular carcinoma treated with sorafenib tosylate showed massive tumor lysis with avoidance of tumor lysis syndrome

Satoru Joshita et al. Intern Med. 2010.
Free article

Abstract

A 33-year-old man presented with pain and palsy of the leg in 2008 for treatment of hepatocellular carcinoma with huge distant metastases. The patient's tumors had slowly enlarged despite several treatments. Oral administration of sorafenib at 800 mg/day with careful observation was commenced in 2009. Laboratory investigations on day 7 showed massive tumor lysis. An abdominal CT showed multiple low density areas and tumor markers decreased, indicating extended tumor necrosis. In conclusion, clinicians should bear in mind not only the published adverse effects, but also massive tumor lysis, when treating patients with large tumor burden by sorafenib.

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Comment in

  • All that glitters: sorafenib.
    Abbass K, Dewani S, Markert R, Kaplon MK, Baumann MA. Abbass K, et al. Intern Med. 2011;50(7):797. doi: 10.2169/internalmedicine.50.4858. Epub 2011 Apr 1. Intern Med. 2011. PMID: 21467725 No abstract available.

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