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. 2010 May 25:6:233-42.
doi: 10.2147/ndt.s3149.

Current trends in drug treatment of obsessive-compulsive disorder

Eric H Decloedt  1 , Dan J Stein
Affiliations

Current trends in drug treatment of obsessive-compulsive disorder

Eric H Decloedt et al. Neuropsychiatr Dis Treat. .

Abstract

This article aims to highlight current trends in the pharmacologic management of obsessive-compulsive disorder (OCD). A systematic search of the electronic database MEDLINE was conducted. The first case report of clomipramine efficacy in the management OCD more than 40 years ago gave new hope for the treatment of this debilitating disorder. Selective serotonin reuptake inhibitors (SSRIs) proved to have a similar efficacy profile compared with clomipramine but had a superior tolerability profile. While many patients with OCD respond to SSRIs or clomipramine, the treatment of those with refractory OCD remains challenging. Different augmentation agents in treatment-resistant OCD have been explored, with antipsychotic agents having the largest supporting evidence base. Nevertheless, new pharmacologic treatment options are required and are under investigation.

Keywords: drug; obsessive–compulsive disorder; pharmacology; treatment.

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References

    1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 2000.
    1. Eisen JL, Mancebo MA, Pinto A, et al. Impact of obsessive-compulsive disorder on quality of life. Compr Psychiatry. 2006;47(4):270–275. - PMC - PubMed
    1. Fontenelle LF, Hasler G. The analytical epidemiology of obsessive- compulsive disorder: Risk factors and correlates. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(1):1–15. - PubMed
    1. Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry. 2010;15(1):53–63. - PMC - PubMed
    1. Torres AR, Prince MJ, Bebbington PE, et al. Obsessive-compulsive disorder: Prevalence, comorbidity, impact, and help-seeking in the British National Psychiatric Morbidity Survey of 2000. Am J Psychiatry. 2006;163(11):1978–1985. - PubMed

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