Some animal models and their probability of extrapolation to man

Abstract

A number of examples of experimental models are presented which are subdivided into models that provide results with a "high" or a "moderate" probability for (qualitative) extrapolation to man. Models with a high predictive value for man are those that produce results that can be directly verified in man or human organs, in contrast with models that have a moderate predictive value, where one has to rely on similarities or analogies of signs and symptoms between man and the animal model. Models with low probability should be rejected.