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. 2009 Dec 1:19:3135-3138.
doi: 10.1055/s-0029-1218293.

Catalytic intermolecular hydroamination of vinyl ethers

Nirmal K Pahadi  1 , Jon A Tunge
Affiliations

Catalytic intermolecular hydroamination of vinyl ethers

Nirmal K Pahadi et al. Synlett. .

Abstract

This manuscript details the development of a palladium-catalyzed hydroamination of vinyl ethers. It is proposed that palladium catalyzes the hydroamination via Bronsted base catalysis, where palladium is protonated by the relatively acidic sulfonamide to generate a palladium hydride as well as the active anionic sulfonamide nucleophile. Thus, this process is distinct from known palladium-catalyzed hydroaminations of styrene derivatives that utilize less acidic amines.

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Scheme 1
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