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. 2009 Aug;41(4):158-61.
doi: 10.4103/0253-7613.56066.

Analgesic and anti-inflammatory activity of Argyreia speciosa root

R S Bachhav  1 , V S Gulecha, C D Upasani
Affiliations

Analgesic and anti-inflammatory activity of Argyreia speciosa root

R S Bachhav et al. Indian J Pharmacol. 2009 Aug.

Abstract

Objective: To study analgesic and anti-inflammatory activities of a methanolic extract (ME) of Argyreia speciosa (AS) root powder.

Materials and methods: The study was carried out using male albino mice (20-25 gm) and male wistar rats (100-150gm). The ME was prepared using soxhlet extraction process. The effect of ME of A. speciosa was investigated for analgesic activity using acetic acid-induced abdominal constriction, tail immersion method and hot plate method. The anti-inflammatory activity of ME of AS roots was studied using carrageenan-induced rat paw edema.

Result: The ME of A. speciosa root was used in pain and inflammation models. The analgesic activity of AS at the dose of (30,100, and 300 mg/kg p.o) showed significant (P<0.01) decrease in acetic acid-induced writhing, whereas ME of A. speciosa at the dose of (100, 300 mg/kg p.o) showed significant (P<0.01) increase in latency to tail flick in tail immersion method and elevated mean basal reaction time in hot plate method. The ME of the A. speciosa at doses (30, 100, and 300mg/kg) showed significant (P < 0.01) inhibition of carrageenan induced hind paw edema in rats.

Conclusion: The ME of A. speciosa showed significant analgesic and anti-inflammatory activity in mice and rat.

Keywords: Argyreia speciosa; analgesic; anti-inflammatory; methanolic extracts.

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Figures

Figure 1
Figure 1
Effect of ME of A. speciosa (30, 100, 300, mg/kg) on acetic acid-induced abdominal constriction in mice
Figure 2
Figure 2
Effect of ME of A. speciosa (30, 100, and 300 mg/kg) on mean reaction time by tail immersion method in mice
Figure 3
Figure 3
Effect of ME of A. speciosa (30, 100, and 300 mg/kg) on mean reaction time by hot plate method in mice
Figure 4
Figure 4
Effect of ME of A. speciosa (30, 100, and 300 mg/kg) on carrageenan-induced rat paw edema
See this image and copyright information in PMC

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