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Case Reports
. 1978 Mar;38(3):367-71.
doi: 10.1111/j.1365-2141.1978.tb01056.x.

Intracellular lambda light chain inclusions in chronic lymphocytic leukaemia

S R McCann, A Whelan, J Greally
Case Reports

Intracellular lambda light chain inclusions in chronic lymphocytic leukaemia

S R McCann et al. Br J Haematol. 1978 Mar.

Abstract

A case of chronic lymphocytic leukaemia (CLL) with intracytoplasmic crystalline inclusions in peripheral blood lymphocytes is presented. The inclusions were identified as crystals of lambda (lambda) light chain and were present in bone marrow derived (B-cells) lymphocytes. The occurrence of light chain crystals in CLL may reflect a more primitive defect in immunoglobulin (Ig) synthesis, intracellular transport or secretion than has previously been reported.

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