Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Nov;170(5):291-313.
doi: 10.1007/s11046-010-9324-3. Epub 2010 Jun 5.

Isavuconazole: a comprehensive review of spectrum of activity of a new triazole

George R Thompson 3rd  1 , Nathan P Wiederhold
Affiliations
Review

Isavuconazole: a comprehensive review of spectrum of activity of a new triazole

George R Thompson 3rd et al. Mycopathologia. 2010 Nov.

Abstract

Isavuconazole is a new triazole currently undergoing phase III clinical trials. This compound has shown in vitro activity against a large number of clinically important yeasts and moulds including Aspergillus spp., Fusarium spp., Scedosporium spp., Candida spp., the Zygomycetes and Cryptococcus spp. Similar to voriconazole, reduced in vitro activity is seen against Histoplasma capsulatum. In vivo efficacy has been demonstrated in murine models of invasive aspergillosis and candidiasis. Additionally, there are several potential pharmacokinetic and drug-drug interaction advantages of this compound over existing antifungal agents. This review summarizes existing data that has been either published or presented at international symposia.

PubMed Disclaimer

References

    1. Mycol Res. 2007 May;111(Pt 5):509-47 - PubMed
    1. Antimicrob Agents Chemother. 2006 Mar;50(3):917-21 - PubMed
    1. Antimicrob Agents Chemother. 2009 Jan;53(1):309-11 - PubMed
    1. Med Mycol. 2009 Feb;47(1):71-6 - PubMed
    1. Antimicrob Agents Chemother. 2009 Apr;53(4):1645-7 - PubMed

MeSH terms

LinkOut - more resources