doi: 10.1021/np100111s.
Triterpene glycosides from Curculigo orchioides and their cytotoxic activity
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- PMID: 20524638
- DOI: 10.1021/np100111s
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Triterpene glycosides from Curculigo orchioides and their cytotoxic activity
J Nat Prod.
.
Abstract
Six new cycloartane glycosides (1-6) were isolated from the rhizomes of Curculigo orchioides. The structures of 1-6 were determined by spectroscopic analyses and the results of hydrolytic cleavage. Compounds 1-6, and their common aglycone (1a), were evaluated for cytotoxic activity against HL-60 human leukemia cells. Compounds 1 and 1a showed cytotoxic activity against HL-60 cells with IC(50) values of 9.0 and 1.8 microM, respectively. The cancer cell growth inhibition of 1a was also examined using a panel of 39 human cancer cell lines in the Japanese Foundation for Cancer Research.
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